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. 2011 Oct 3;121(11):4491–4502. doi: 10.1172/JCI38760

Figure 3. Transcriptional regulation by CAR.

Figure 3

(A) CAR translocation. Immunoperoxidase detected a weak diffuse reaction to CAR in the cytoplasm of untreated hepatocytes. 3 hours after treatment with TCPOBOP, there was clear demonstration of nuclear CAR. Gadd45b–/– and wild-type genotypes were indistinguishable. Original magnification, ×400. (B) Quantification of 6 representative mRNAs. Real time RT-PCR analysis was carried out as in Figure 1C. Data are mean ± SD. *P < 0.05; **P < 0.01, Gadd45b–/– vs. wild-type, t test.