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. 2011 Oct 24;121(11):4303–4310. doi: 10.1172/JCI46187

Figure 1. Cells from NOD mice generate Th17 cells more efficiently than cells from NOD.Idd3 mice.

Figure 1

Naive T cells were polarized with TGF-β and IL-6. After 3 days, cells were restimulated with PMA and ionomycin in the presence of monensin for 4 hours before cell surface and then intracellular staining. Values in each quadrant represent the percentage of 7-AAD–CD4+ cells. Cells were activated with (A) plate-bound anti-CD3 and soluble anti-CD28 or (B) with soluble anti-CD3 in the presence of APCs, with or without anti–IFN-γ mAb. Data shown are representative of 4 to 9 experiments.