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. 2011 Oct 17;121(11):4244–4256. doi: 10.1172/JCI57728

Figure 6. Stat1–/– mice have low CD8+ cells and high Th2 markers after RRV challenge.

Figure 6

Flow cytometric analyses showing the percentage of hepatic CD4+ and CD8+ T cells and CD4/CD8 ratios in WT and Stat1–/– mice after RRV (A–C). (D) RRV titer shows clearance of RRV by WT mice and persistently high titers in Stat1–/– mice. (E) Graphs display hepatic mRNA expression for Th1 and Th2 genes in WT and Stat1–/– mice after RRV challenge. mRNA expression was first normalized to internal Hprt control and then normalized to the value from WT mice at day 3; n = 3–4 livers per group and time point. *P < 0.05; **P < 0.01; ***P < 0.001. Values are expressed as mean ± SEM.