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. 2011 Oct 17;121(11):4244–4256. doi: 10.1172/JCI57728

Figure 8. Loss of IL-13 but not Stat6 decreases biliary obstruction in Stat1–/– mice.

Figure 8

Flow cytometric analysis of phosphorylated Stat6 in hepatic and splenic CD4+ T cells shows Stat6 activation in CD4+ T cells in the absence of Stat1 (A). (B) Graphs show the hepatic mRNA expression for receptors shared by IL-4 and IL-13 at 7 days after RRV challenge. (C) Photomicrographs of longitudinal sections of extrahepatic bile ducts of Stat1–/– and Stat1–/–Il13–/– mice 7 days after RRV challenge. (D–H) Flow cytometric analyses of hepatic mononuclear cells 10 days after RRV challenge in WT, Stat1–/–, and Stat1–/–Il13–/– mice. Surface staining was used for D and E, while dual surface and intracellular stainings were used for F–H; n = 3–5 in each group. **P < 0.01; ***P < 0.001. Values are expressed as mean ± SEM.