Table 2.

Interactive effects of Major Depression and Tobacco Use on Obesity, and Simple Effect analyses

	Unadjusted	Adjustede
Outcome: Obese vs. Non-Obese (BMI ≥ 30)c
Smoking Status × MD interactiona	Wald χ2= 14.4, p = .0001	Wald χ2= 14.3, p < .0001
Effect of MD among Nonsmokers	OR(95% CI) = 1.72(1.53–1.94), p < .0001	OR(95% CI) = 1.43(1.25–1.63), p < .0001
Effect of MD among Smokers	OR(95% CI) = 1.15(0.97–1.37), p = .10	OR(95% CI) = 1.12(0.93–1.36), p = .23
TD × MD interactionb	Wald χ2= 11.5, p = .0007	Wald χ2= 12.5, p = .0004
Effect of MD among TD- respondents	OR(95% CI) = 1.65(1.47–1.84), p < .0001	OR(95% CI) = 1.40(1.24–1.58), p < .0001
Effect of MD among TD+ respondents	OR(95% CI) = 1.08(0.81–1.34), p = .49	OR(95% CI) = 1.06(0.83–1.35), p = .67
Outcome: Continuous BMI valued
Smoking Status × MD interactiona	F = 24.6, p < .0001	F = 21.1, p < .0001
Effect of MD among Nonsmokers	F = 56.4, p < .0001	F = 34.0, p < .0001
Effect of MD among Smokers	F = 0.2, p = .68	F = 0.4, p = .55
TD × MD interactionb	F = 13.6, p = .0002	F = 13.5, p = .0002
Effect of MD among TD- respondents	F = 49.1, p < .0001	F = 26.7, p < .0001
Effect of MD among TD+ respondents	F = 0.1, p = .72	F < 0.01, p = .98

Note. N = 41654. Smoking Status = Smoked Tobacco in past 12 months (Nonsmoker, n = 30768; Smoker = 10886); MD = Major Depression in past 12 months excluding substance-induced (MD-, n = 38238; MD+, n = 3416); TD = Tobacco Dependence in past 12 months (TD-, n = 36769; TD+, n = 4885).

^aEffects of interaction term in models including MD, smoking status, and their interaction as predictors.

^bEffects of interaction term in models including MD, TD, and their interaction as predictors

^cLogistic Regression Models.

^dLinear Regression Models.

^eAdjusted for age, sex, ethnicity/race, marital status, education, urbanicity, and lifetime history of anxiety, manic, personality, alcohol use, and drug use disorder