. Author manuscript; available in PMC: 2012 Sep 27.

Published in final edited form as: Chem Mater. 2011 Sep 27;23(18):4227–4233. doi: 10.1021/cm201628z

Table 1.

Nitric oxide release characteristics for PPI dendrimers in PBS (pH = 7.4) at 37 °C.

Dendrimer		t[NO] (μmol NO/mg)^a	t[NO] (μmol NO/μmol)^b	[NO]_max (ppb/mg)^c	[NO]_max (ppb/μmol)^d	t_½ (h)	Conversion (%)
a-8-NO	G2-PPI-ACN-NO	3.57	4.18	1529	1788	4.81	26.1
a-16-NO	G3-PPI-ACN-NO	3.33	8.35	1100	2758	4.84	26.1
a-32-NO	G4-PPI-ACN-NO	2.45	12.7	1547	7977	4.82	19.9
a-64-NO	G5-PPI-ACN-NO	1.68	17.7	881	9282	4.88	13.8

b-8-NO	G2-PPI-PEG-NO	1.11	5.10	3771	17291	0.67	31.9
b-16-NO	G3-PPI-PEG-NO	1.08	10.1	2309	21564	1.11	31.6
b-32-NO	G4-PPI-PEG-NO	1.37	25.8	4088	77035	0.84	40.3
b-64-NO	G5-PPI-PEG-NO	1.17	44.3	1886	71403	1.22	34.6

c-8-NO	G2-PPI-PO-NO	2.99	3.63	17130	20725	0.30	22.7
c-16-NO	G3-PPI-PO-NO	3.22	8.38	9617	24888	0.62	26.2
c-32-NO	G4-PPI-PO-NO	3.27	17.5	7762	41481	0.78	27.3
c-64-NO	G5-PPI-PO-NO	3.78	41.1	6839	74250	1.06	32.1

d-8-NO	G2-PPI-SO-NO	1.14	1.95	8495	14496	1.47	12.2
d-16-NO	G3-PPI-SO-NO	0.91	3.30	2363	8462	0.97	10.3
d-32-NO	G4-PPI-SO-NO	1.18	8.70	1720	12609	1.43	13.6
d-64-NO	G5-PPI-SO-NO	1.25	18.5	2215	32843	1.62	14.5

e-8-NO	G2-PPI-ED-NO	1.95	3.87	5648	11178	0.81	24.2
e-16-NO	G3-PPI-ED-NO	1.64	6.75	2733	11279	1.71	21.1
e-32-NO	G4-PPI-ED-NO	1.51	12.8	2401	20217	1.34	19.9
e-64-NO	G5-PPI-ED-NO	1.86	31.6	3190	54262	1.88	24.7

total amount of NO release (μmol) per milligram of secondary amine-functionalized PPI.

total amount of NO release (μmol) per micromole of secondary amine-functionalized PPI.

maximum flux of NO release (ppb) per milligram of secondary amine-functionalized PPI.

maximum flux of NO release (ppb) per micromole of secondary amine-functionalized PPI.