Table.

Frequency of Neuropsychiatric Features among PPA and Cognitively Normal Participants^*

NPI domain	Normal N=110 (%)	PPA N=55 (%)	OR (95% CI)	P-value
Depression/Dysphoria	6 (5.5)	21 (38.2)	12.56 (3.72, 42.4)	<0.001
Night-time Behavior	13 (11.8)	12 (21.8)	2.00 (0.87, 4.61)	0.10
Irritability/Lability	3 (2.7)	10 (18.2)	9.29 (2.02, 42.7)	0.004
Agitation	1 (0.9)	11 (20.0)	22.00 (2.84, 170.4)	0.003
Aberrant Motor Behavior	0 (0.0)	13 (23.6)	N/A
Disinhibition	0 (0.0)	11 (20.0)	N/A
Anxiety	1 (0.9)	8 (14.8)	16.00 (2.00, 127.9)	0.009
Appetite/Eating Change	3 (2.7)	14 (25.9)	9.33 (2.68, 32.5)	<0.001
Apathy/Indifference	4 (3.6)	26 (48.1)	24.53 (5.81, 103.6)	<0.001
Euphoria/Elation	0 (0.0)	5 (9.3)	N/A
Delusions	1 (0.9)	4 (7.4)	8.00 (0.89, 71.6)	0.063
Hallucinations	0 (0.0)	0 (0.0)	N/A

^*Adjusted for age, sex, education (by matched case-control design) and functional status (CDR) by statistical analysis.