Table 1. QTL mapping and correlation with gene expression revealed eight candidate genes for influencing hippocampal activity.
trait | location QTL | LRS | genes | Correlation | p-value |
Amplitude 1–45 Hz (ACSF) | chr 5 16.522–22.723 | 14.6 | Psmc2 | −0.63 | 0.01 |
Correlation (ACSF) | chr 4 39.167–44.254 | 15.1 | Dctn3 | −0.59 | 0.04 |
Creb3 | −0.59 | 0.04 | |||
Amplitude 1–45 Hz (CCH) | chr 1 156.371–160.384 | 12.4 | Ralgps2 | 0.61 | 0.03 |
Cacna1e | 0.62 | 0.01 | |||
Peak amplitude | chr 2 132.507–135.784 | 18.2 | Plcb1 | 0.58 | 0.02 |
chr 2 22.673–25.693 | 12.2 | Cacna1b | 0.57 | 0.03 | |
Peak frequency | chr17 72.002–76.447 | 12.6 | Ehd3 | 0.60 | 0.005 |
Each row contains the information belonging to one candidate gene. Indicated are the hippocampal activity trait associated with the gene, the location of the QTL (chr = chromosome, location in Megabases) that harbors the gene found, the LRS score of the QTL, the gene symbol, the correlation between trait and level of expression of the gene, and finally the p-value from the correlation, computed with a permutation test.