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. 2011 Oct 31;6(10):e27034. doi: 10.1371/journal.pone.0027034

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mdx and wt whole heart crude lysates were fractionated into the membrane (mem) and cytosolic fraction (cyt) and analyzed by western analysis with antibodies specific for dystrophin (top panel), BK (middle panel) and CKm (bottom panel). Note the presence of CKm in the membrane fraction of only the wt lysate while BK, which was used as a control, is present in both the wt and the mdx samples. The partial degradation for Dys427 is due to the extraction without detergent, required for the membrane separation. Multiple BK bands are due to different glycosylation state of the protein during synthesis.