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. 2011 Oct 31;6(10):e27145. doi: 10.1371/journal.pone.0027145

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Nickerson et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A–D) P3 marks the earliest age at which Vsx2-5.3-PRE-Cre can be detected by immunofluorescence. Strong, Cre-immunolabeled nuclei (A) co-label with Vsx2 (B) within the inner region of the Vsx2-positive neuroblastic layer (demarcated with dashed lines in C). Inset (D–F) shows high magnification view of examples of Cre/Vsx2 double-labeled nuclei (arrowheads) within the NBL (box in (C)). (G–I) By P6, a robust up-regulation of Vsx2-5.3-PRE-Cre is evident in Vsx2-expressing cells located throughout the NBL, although the majority of these cells localize at the apical margin of the NBL. Insets (J–L) show a high magnification view of the apical NBL. The presence of Cre-negative/Vsx2-positive nuclei located at the apical NBL boundary (arrows) may represent a newly postmitotic (G1) cell arriving to the Cre-expressing layer.