Table 6.

Plasma pharmacokinetic parameters for PR-104A metabolites, cycle 1 day 1

		Cmax (μM)				AUC (μM h)				t1/2 (h)
Dose-level (mg/m2)	n	PR-104G	PR-104H	PR-104M	PR-104S1	PR-104G	PR-104H	PR-104M	PR-104S1	PR-104G	PR-104H	PR-104M	PR-104S1
135	2	1.66	0.66	0.05	0.06	1.67	0.79	0.08	0.10	0.25	0.48	0.53	0.76
270	6	3.02 (2.12)	0.68 (0.29)	0.06 (0.02)	0.14 (0.09)	3.96 (3.81)	0.81 (0.37)	0.11 (0.05)	0.25 (0.17)	0.40 (0.22)	0.51 (0.12)	0.88 (0.43)	1.09 (0.51)
540	6	11.27 (8.07)	0.49 (0.17)	0.07 (0.02)	0.20 (0.08)	13.85 (12.01)	0.63 (0.26)	0.11 (0.04)	0.29 (0.13)	0.38 (0.14)	0.41 (0.12)	0.56 (0.15)	0.59 (0.23)
675	7	8.71 (4.52)	0.51 (0.27)	0.08 (0.05)	0.36 (0.25)	11.9 (7.4)	0.71 (0.32)	0.13 (0.06)	0.49 (0.45)	0.49 (0.17)	0.74 (0.37)	0.75 (0.28)	0.68 (0.12)
900	4	7.81 (3.92)	0.39 (0.16)	0.07 (0.03)	0.31 (0.13)	11.19 (6.54)	0.69 (0.26)	0.16 (0.08)	0.64 (0.25)	0.68 (0.18)	0.85 (0.09)	0.88 (0.11)	0.79 (0.15)

Values are the mean (SD)