Table 6.
Cmax (μM) | AUC (μM h) | t1/2 (h) | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dose-level (mg/m2) | n | PR-104G | PR-104H | PR-104M | PR-104S1 | PR-104G | PR-104H | PR-104M | PR-104S1 | PR-104G | PR-104H | PR-104M | PR-104S1 |
135 | 2 | 1.66 | 0.66 | 0.05 | 0.06 | 1.67 | 0.79 | 0.08 | 0.10 | 0.25 | 0.48 | 0.53 | 0.76 |
270 | 6 | 3.02 (2.12) | 0.68 (0.29) | 0.06 (0.02) | 0.14 (0.09) | 3.96 (3.81) | 0.81 (0.37) | 0.11 (0.05) | 0.25 (0.17) | 0.40 (0.22) | 0.51 (0.12) | 0.88 (0.43) | 1.09 (0.51) |
540 | 6 | 11.27 (8.07) | 0.49 (0.17) | 0.07 (0.02) | 0.20 (0.08) | 13.85 (12.01) | 0.63 (0.26) | 0.11 (0.04) | 0.29 (0.13) | 0.38 (0.14) | 0.41 (0.12) | 0.56 (0.15) | 0.59 (0.23) |
675 | 7 | 8.71 (4.52) | 0.51 (0.27) | 0.08 (0.05) | 0.36 (0.25) | 11.9 (7.4) | 0.71 (0.32) | 0.13 (0.06) | 0.49 (0.45) | 0.49 (0.17) | 0.74 (0.37) | 0.75 (0.28) | 0.68 (0.12) |
900 | 4 | 7.81 (3.92) | 0.39 (0.16) | 0.07 (0.03) | 0.31 (0.13) | 11.19 (6.54) | 0.69 (0.26) | 0.16 (0.08) | 0.64 (0.25) | 0.68 (0.18) | 0.85 (0.09) | 0.88 (0.11) | 0.79 (0.15) |
Values are the mean (SD)