Table 7.
Lack of change in plasma AUCs (μM.h) of PR-104, PR-104A and metabolites with repeat dosing of PR-104 at 675 mg/m2 on cycle 1 day 1 (C1D1), cycle 1 day 8 (C1D8) and cycle 2 day 1 (C2D1)
| Patient | Cycle | PR-104 | PR-104A | PR-104G | PR-104H | PR-104M | PR-104S1 |
|---|---|---|---|---|---|---|---|
| 04-75 | C1D1 | 6.34 | 12.11 | 6.60 | 0.51 | 0.06 | 0.16 |
| C1D8 | 6.61 | 13.16 | 7.74 | 0.44 | 0.09 | 0.16 | |
| 01-76 | C1D1 | 6.76 | 14.14 | 21.38 | 0.56 | 0.11 | 0.87 |
| C1D8 | 7.91 | 16.72 | 28.01 | 0.45 | 0.10 | 1.09 | |
| 04-77 | C1D1 | 14.55 | 17.81 | 7.07 | 0.25 | 0.12 | 0.31 |
| C1D8 | 11.01 | 16.96 | 7.53 | 0.26 | 0.12 | 0.36 | |
| C2D1* | 8.16 | 19.53 | 6.73 | 0.59 | 0.10 | 0.44 |
*, given with naproxen.