Table 8.

Correlations between drug exposure and toxicity, normalised drug exposure and creatinine clearance (Spearman rank order analysis).

Exposure	platelets†	neutrophils†	CrCl‡
Dose	-0.79 (2 × 10-7)	-0.56 (5 × 10-3)	-
PR-104 AUC	-0.56 (0.005)	-0.35 (0.1)	-0.14 (0.52)
PR-104A AUC	-0.75 (2 × 10-7)	-0.49 (0.02)	-0.12 (0.59)
PR-104G AUC	-0.51 (0.01)	-0.13 (0.56)	-0.01 (0.98)
PR-104(H+M) AUC	0.09 (0.67)	-0.04 (0.84)	-0.04 (0.86)
PR-104S1 AUC	-0.61 (0.002)	-0.53 (0.009)	-0.16 (0.46)

^†At nadir (percentage of pretreatment value)

^‡Creatinine clearance. Drug exposures (AUC) are normalised by dose levels.

Values are correlation coefficient and (p value).