Chairman: James Bassingthwaighte
Monday, September 17
Welcome	Barbara Packard
	Director, DHVD, NHLBI
Introduction	James Bassingthwaighte
Session I: Metabolism overview: current dilemmas and future directions
Moderator: Jeanie McMillin-Wood
Carbohydrate interconversions and energy production	Heinrich Taegtmeyer
Fatty acid, triacylglycerol, and ketone body metabolism	Loran Bieber
Nitrogen metabolism and protein synthesis/degradation mechanisms	Radovan Zak
Metabolic pathways of energy metabolism: assessment by nuclear magnetic resonance	Truman Brown
Metabolic tracer imaging with positron-emission tomography	Burton Sobel
Session II: Kinetics of substrate transport and reaction
Moderators: James Bassingthwaighte and Kenneth Zierler
Overview: Processes of delivery, transport, reaction, and retention	James Bassingthwaighte
The modeling process	Kenneth Larson
Heterogeneity within the observed regions: physiological basis and effect on estimation of rates	Ludvik Bass
The acquisition of data for quantitative analysis	Thomas Budinger
Model simplification: complexity versus reduction	Michael Graham
Panel and open discussion: recommendations for developments in analysis of metabolic events via images
Critique of session	Kenneth Zierler
Discussion	Ludvik Bass, James Basssingthwaite, Thomas Budinger, Albert Gjedde, Michael Graham, and Kenneth Larson
Monday evening, September 17 (concurrent sessions)
Session III. Influences of flows and transmembrane transport on tracer uptake retention
Moderators: Thomas Budinger and Albert Gjedde
Influences of flow on substrate uptake	James Holden
Error in parameter estimates with variations in flow	Sung-Cheng Huang
A proposed model system for studying receptor kinetics	Kenneth Krohn
Estimation of membrane transport rates in the absence of regional flow measurement	Carl Goresky
Effects of reflux from the cell on the interpretation of deposition images	Michael Phelps
Moderators' summary: Thomas Budinger and Albert Gjedde
Session IV. NMR kinetic measurements
Moderators: Truman Brown and Joanne Ingwall
Use of shift reagents for kinetics of ion transfer	Charles Springer
Magnetization transfer techniques	Kamil Ugurbil
Metabolic studies using 13C	Jan den Hollander
Spectroscopic localization techniques	Felix Wehrli
Moderators' summary: Truman Brown and Joanne Ingwall
Tuesday, September 18
Session V. Myocardial disease
Moderator: Heinrich Schelbert
Critical problems in myocardial disorders
Need for noninvasive studies of regional myocardial metabolism in clinical cardiology	Edmund Sonnenblick
Biochemical abnormalities in cardiac diseases	Arnold Katz
Approaches to future studies using NMR
Spectroscopy in vivo	Britton Chance
NMR imaging: potential for metabolic studies	Gerald Pohost
Approaches to future studies of the disease process using positron emission tomography
Assessment of substrate metabolism	Heinrich Schelbert
Krebs cycle, oxygenation, and oxidation	Terry Jones
Assessment of cardiac receptors	William Eckelman
Synopsis and summary	Henry Wagner
Session VI. Animal model studies
Moderator: Truman Brown
What is needed in an animal model	Michael Rovetto
Specific cardiac models	James Scheuer
Metabolic and physiological model studies using PET	Jeanie McMillin-Wood
Metabolic and physiological model studies using NMR	Robert Balaban
Future opportunities	Thomas Smith
Summary: meeting overview	Philip Randle