Table 3.
Summary of side effects seen with increasing doses of CTI 52010 using the Veterinary Co-operative Oncology Group (VCOG) – common criteria for adverse events version 1 criteria following chemotherapy (see also Table 2). Each cell represents a single adverse event in one dog
| Side effect | Vomiting (Grade) | Nausea (Grade) | Neutropenia (Grade) | Thrombocytopenia (Grade) |
|---|---|---|---|---|
| Dose (mg/m2) | ||||
| 40 | Grade 1 | |||
| 60 | ||||
| 80 | Grade 2 | Grade 1 | ||
| 90 | Grade 1 | Grade 1 | Grade 1 | |
| 120 | Grade 1 | |||
| 160 | Grade 2 | Grade 4 (DLT) | Grade 3 | |
| 240 | Grade 1 | Grade 4 (DLT) | Grade 1 | |
Note: Copyright© 2004. John Wiley and Sons. Reproduced with permission from Veterinary Cooperative Oncology Group. Veterinary Co-operative oncology group – common criteria for adverse events (VCOG–CTCAE) following chemotherapy or biological antineoplastic therapy in dogs and cats v1.0. Vet Comp Oncol. 2004;2:194–213.14
Abbreviation: DLT, dose-limiting toxicity.