Table 4.
Pharmacokinetic parameters for CTI 52010 determined after intravenous administration
| Parameter | Dosage | 60 mg/m2 | 80 mg/m2 | 90 mg/m2 | 120 mg/m2 | 160 mg/m2 | 240 mg/m2 |
|---|---|---|---|---|---|---|---|
| AUC (ng-hr/mL) | 891 | 577 | 509 | 285 | 1304 | 1316 | |
| t1/20–24 | 203.4 | 116.3 | 42.7 | 9.9 | 37.2 | 24.7 | |
| Vd (L) | 2288 | 2522 | 2749 | 2289 | 1691 | 2251 | |
| Cmax (ng/mL) | 3545 | 327 | N/A | 319 | 4531 | 2020 | |
| MRT (area in hours) | 258 | 161 | 57 | 8.8 | 37.8 | 29.8 |
Abbreviations: AUC, area under the curve; MRT, mean residence time; t1/2, elimination half-life; Cmax, peak plasma concentration.