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Maximum tolerated dose and 50% lethal dose values of methotrexate and LDE-ddMTX intravenously administered as a single dose in Balb/c mice
| Formulations | Single dose | |
|---|---|---|
| MTD | LD50 | |
| LDE-ddMTX | 47 mg/kg | 115 mg/kg |
| MTX | 94 mg/kg | 470 mg/kg |
Abbreviations: ddMTX, didodecyl methotrexate; MTX, methotrexate; LDE, lipid nanoemulsion; LD50, 50% lethal dose; MTD, maximum tolerated dose.
