Table 2.
Hematological profile of rabbits treated with LDE-etoposide (6 mg/kg body weight/week) or saline solution (control group), for 8 weeks
| Control (n = 9) | LDE-etoposide (n = 9) | |||
|---|---|---|---|---|
| Baseline | 8th week | Baseline | 8th week | |
| Red blood cells (109/mL) | 5.7 ± 1.0 | 4.4 ± 1.6 | 6.0 ± 1.0 | 2.9 ± 0.8a,b |
| Leuckocytes (106/mL) | 6.6 ± 1.0 | 7.6 ± 3.1 | 7.6 ± 3.5 | 6.9 ± 2.9 |
| Lymphocytes (%) | 72.8 ± 4.7 | 62.7 ± 11.6 | 68.2 ± 7.9 | 73.7 ± 9.9 |
| Monocytes (%) | 5.6 ± 5.0 | 10.8 ± 5.4 | 7.0 ± 3.9 | 5.9 ± 3.7 |
| Neutrophils (%) | 18.9 ± 9.9 | 26.6 ± 10.2 | 25.9 ± 7.4 | 20.4 ± 9.3 |
Notes: Data are expressed as mean ± SD.
a
P < 0.001 versus baseline;
b
P < 0.001 versus 8th week control.