Table 5.
Protein expression (%) of inflammation and proliferation markers and lipoprotein receptors, evaluated by immunohistochemistry of aorta of rabbits treated with LDE-etoposide (6 mg/kg body weight/week) or saline solution (control group), for 8 weeks
| Control (n = 9) | LDE-etoposide (n = 9) | |
|---|---|---|
| RAM-11 | 67.73 ± 13.03 | 26.96 ± 28.46b |
| VSMC | 27.52 ± 10.63 | 7.89 ± 9.06a |
| IL-1β | 55.41 ± 17.82 | 24.82 ± 22.69b |
| TNF-α | 20.04 ± 15.77 | 5.57 ± 6.42c |
| MMP-9 | 14.98 ± 8.59 | 6.44 ± 8.41a |
| PCNA | 3.53 ± 3.90 | 4.51 ± 4.55 |
| Topoisomerase IIα | 42.46 ± 15.77 | 8.51 ± 10.35c |
| Tubulin | 47.40 ± 15.38 | 16.01 ± 19.82b |
| LDL receptor | 35.13 ± 20.13 | 11.28 ± 16.80a |
| LRP-1 | 41.94 ± 21.35 | 5.11 ± 9.92c |
| CD-36 | 40.13 ± 15.26 | 8.60 ± 13.54c |
| SR-B1 | 19.86 ± 8.26 | 4.87 ± 8.65b |
Notes: Data are expressed as mean ± SD.
a
P < 0.05 versus control;
b
P < 0.01 versus control;
c
P < 0.001 versus control.