Table 2.
Changes in serum biochemical parameters (A) and lipid profile (B) 28 days after the intratracheal instillation of cerium oxide nanoparticles
| Analyte | Saline control (n = 7) | CeO2 1.0 mg/kg (n = 7) | CeO2 3.5 mg/kg (n = 7) | CeO2 7.0 mg/kg (n = 7) |
|---|---|---|---|---|
| A | ||||
| Glucose | 186.4 ± 25.7 | 208 ± 43.0 | 197.6 ± 40.2 | 231 ± 93.5 |
| ALP | 276.1 ± 53.7 | 263 ± 55.4 | 242 ± 35.3 | 222.23 ± 81.9 |
| ALT | 58.3 ± 10.7 | 83.4 ± 28.5 | 88.3 ± 31.4 | 130.5 ± 94.5* |
| Amylase | 974.7 ± 97.4 | 1055.1 ± 124.2 | 991.4 ± 116 | 908.4 ± 277.0 |
| Total protein | 6.0 ± 0.1 | 5.9 ± 0.6 | 6.2 ± 0.5 | 5.4 ± 1.3 |
| Albumin | 4.2 ± 0.2 | 4.1 ± 0.5 | 4.5 ± 0.4 | 3.5 ± 1.1* |
| Globulin | 1.8 ± 0.2 | 1.8 ± 0.2 | 2.0 ± 0.2 | 1.8 ± 0.2 |
| ALB-GLOB ratio | 2.3 ± 0.3 | 2.3 ± 0.3 | 2.2 ± 0.3 | 1.9 ± 0.6 |
| BUN | 15.4 ± 1.1 | 15 ± 3.1 | 15.7 ± 1.9 | 14.4 ± 4.2 |
| Creatinine | 0.3 ± 0.1 | 0.27 ± 0.1 | 0.23 ± 0.1 | 0.28 ± 0.1 |
| Ca2+ | 11.4 ± 0.7 | 10.7 ± 1.3 | 11.5 ± 1.1 | 10.4 ± 2.4 |
| Phosphorus | 8.6 ± 0.9 | 7.9 ± 1.2 | 8.7 ± 1.0 | 8.2 ± 1.9 |
| Na+ | 142.3 ± 0.9 | 138 ± 10.7 | 138.1 ± 10.7 | 132.1 ± 16.3 |
| K+ | 5.5 ± 0.4 | 6.0 ± 0.5 | 6.5 ± 0.6 | 5.8 ± 0.9 |
| Na+-K+ ratio | 25.8 ± 2.0 | 22.9 ± 1.7* | 21.2 ± 1.4* | 22.8 ± 2.5* |
| B | ||||
| Total cholesterol | 100.7 ± 1.9 | 100 ± 0 | 100 ± 0 | 103.1 ± 8.3 |
| Triglycerides | 143 ± 53 | 109.6 ± 50.9 | 190.3 ± 83.7 | 93.1 ± 22.3* |
| HDL | 21 ± 6.0 | 19.4 ± 5.4 | 20 ± 6.4 | 19 ± 5.1 |
*
Note: Significantly different from the vehicle control (P < 0.05).
Abbreviations: ALP, alkaline phosphatase; ALT, alanine aminotransferase; ALB-GLOB ratio, albumin to globulin ratio; BUN, blood urea nitrogen; Ca, calcium; Na, sodium; K, potassium; Na-K ratio, sodium to potassium ratio; HDL, high density lipoproteins.