Table 1.
Kinetic drug release values of different budesonide formulations
| Preparations | Adjusted coefficient of determination (R2 adjusted) | Release rate constant | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Zero-order | First-order | Higuchi | Baker-Lonsdale model | Hixson-Crowell model | Zero-order (K0) (μg/hour) | First-order (k1) (per hour) | Higuchi (kH) (μg/h0.5) | Baker-Lonsdale | |
| BUD-SSMs | 0.76 ± 0.05 | 0.91 ± 0.01 | 0.97 ± 0.01 | 0.97 ± 0.01 | 0.88 ± 0.01 | / | / | 9.04 ± 0.48 | 0.002 ± 0.00 |
| Pulmicort Respules® | 0.23 ± 0.30 | 0.98 ± 0.01 | 0.90 ± 0.03 | / | / | / | 0.65 ± 0.09 | / | / |
Abbreviation: BUD-SSMs, PEG5000-DSPE polymeric micelles containing budesonide.