Table 2.
Aerodynamic characteristics of different budesonide formulations
| Preparations | Pulmicort Respules® | BUD-SSMs |
|---|---|---|
| MMAD (μm) | 4.48 ± 0.12 | 2.83 ± 0.08 |
| GSD (μm) | 2.01 ± 0.03 | 2.33 ± 0.04 |
| ED (%) | 39.73 ± 0.53 | 59.13 ± 0.19 |
| FPF(<2.8 μm) (%) | 15.48 ± 0.61 | 36.51 ± 0.19 |
| FPF(<4.4 μm) (%) | 29.76 ± 0.36 | 52.31 ± 0.25 |
| Percent of drug remaining in nebulizer | 56.38 ± 1.40 | 40.70 ± 0.63 |
| Percent of drug deposited in induction port | 4.39 ± 0.66 | 2.24 ± 0.27 |
Abbreviations: BUD-SSMs, PEG5000-DSPE polymeric micelles containing budesonide; MMAD, mass median aerodynamic; GSD, geometric standard deviation; ED, emitted dose; FPF, fine particle fraction.