Figure 3.

Antitumor effect of ms-T34A-HPEI on subcutaneous C-26 tumor models in vivo. (A) Transfection ability of HPEI was evaluated in vivo, while Lac-Z gene was used as the report gene. Blue staining means the gene expression, and (B) tumor volume of each treatment group. Mice bearing C-26 tumors were treated with NS, HPEI, null-HPEI, or ms-T34A-HPEI every three days for five doses (5 μg DNA/dosage).

Note: There was a significant difference in tumor volume between ms-T34A-HPEI and the controls (P < 0.05).

Abbreviations: HPEI, heparin-polyethyleneimine; ms-T34A, mouse survivin-T34A; NS, normal saline.