Table 4.
Cutaneous pharmacokinetic parameters of evodiamine and rutaecarpine from various skin regions in rats (mean ± standard deviation, n = 5)
| Parameter | Evodiamine | Rutaecarpine | ||||
|---|---|---|---|---|---|---|
| Abdomen | Chest | Shoulder | Abdomen | Chest | Shoulder | |
| Tmax (minutes) | 480.00 ± 21.35 | 120.00 ± 11.32 | 180.00 ± 12.58 | 450.00 ± 17.28 | 150.00 ± 6.94 | 180.00 ± 13.66 |
| Cmax (ng/mL) | 18.23 ± 1.54 | 8.20 ± 0.91 | 4.24 ± 0.49 | 16.04 ± 0.96 | 7.11 ± 0.75 | 3.77 ± 0.52 |
| MRT0–t (minutes) | 307.77 ± 10.28 | 308.69 ± 25.87 | 312.60 ± 14.30 | 319.11 ± 25.11 | 303.14 ± 8.72 | 290.37 ± 21.43 |
| AUC0–t (ng/mL × minutes) | 9368.34 ± 104.52 | 3808.92 ± 86.13 | 2088.33 ± 91.36 | 7878.33 ± 87.23 | 3358.77 ± 69.54 | 1653.84 ± 71.20 |
Abbreviations: AUC, area under the curve; Cmax, maximum concentration; MRT, mean residence time; Tmax, time to reach Cmax.