Table 2.

Orthogonal design and responses

Run	Brij 78 (mg/mL)	TPGS (mg/mL)	Temperature (°C)	Entrapment (%)	Size (nm)
1	3.7	1.2	50	36.25	219.7
2	1.7	0.4	55	66.66	202.4
3	3.7	0.8	55	44.44	198.2
4	2.7	0.8	60	54.88	198.4
5	1.7	0.8	50	65.12	202.9
6	2.7	0.4	50	51.46	189.3
7	2.7	1.2	55	52.15	204.0
8	1.7	1.2	60	46.49	198.0
9	3.7	0.4	60	45.89	184.0

Notes: Miglyol 808 concentration was 2.5 mg/mL for all 9 runs. C12-DX concentration was 0.5 mg/mL for all 9 runs.

Abbreviations: TPGS, tocopheryl polyethylene glycol succinate; DX, docetaxel.