Table 4B.

Pharmacokinetic parameters of DX after iv bolus administration of DX conjugates and Taxotere in mice

	Taxotere	C12-DX NP	C18-DX NP	C22-DX NP
t1/2 (hours)	3.63	1.09	5.42	−a
AUC0–24 (h*mg/L)	1.51	4.64	3.51
AUC0–∞ (h*mg/L)	1.55	4.66	3.66
Kel (1/hour)	0.19	0.63	0.13
Cmax (mg/L)	7.21	12.31	0.74
MRT (hours)	0.87	0.89	6.98

^aNote: Below lower limit of quantification.

Abbreviations: DX, docetaxel; AUC, area under the curve; MRT, mean retention time.