Table 2.
Bivariate Analysis of Characteristics Associated With Serological Cure and Serofast Status at 6 Months
| Characteristic | Serological cure, no. (%) of participants (n = 369) | Serofast status, no. (%) of participants (n = 96) | OR (95% CI) |
| Sex | |||
| Male | 234 (81.5) | 53 (18.5) | 1.41 (.89–2.22) |
| Female | 135 (75.8) | 43 (24.1) | 1 |
| Age, years | |||
| ≤24 | 198 (86.8) | 30 (13.2) | 3.30 (1.67–6.54) |
| 25–29 | 84 (83.2) | 17 (16.8) | 2.47 (1.15–5.33) |
| 30–39 | 51 (62.2) | 31 (37.8) | 0.82 (.40–1.69) |
| ≥40 | 36 (66.7) | 18 (33.3) | 1 |
| Race/ethnicity | |||
| Black | 54 (83.1) | 11 (16.9) | 1 |
| White or other | 11 (78.6) | 3 (21.4) | 0.75 (.18–3.13) |
| Malagasy | 304 (78.8) | 82 (21.2) | 0.76 (.38–1.51) |
| Sexual orientation | |||
| Homosexuala | 12 (85.7) | 2 (14.3) | 1 |
| Heterosexual | 353 (79.3) | 92 (20.7) | 0.64 (.14–2.91) |
| Bisexual | 3 (60.0) | 2 (40.0) | 0.25 (.02–2.58) |
| No. of sex partners in past 6 months | |||
| 0–1 | 135 (84.4) | 25 (15.6) | 1 |
| 2–5 | 182 (81.6) | 41 (18.4) | 0.82 (.48–1.42) |
| 6–10 | 32 (69.6) | 14 (30.4) | 0.43 (.20–.90) |
| >10 | 20 (55.6) | 16 (44.4) | 0.23 (.11–.51) |
| History of syphilis | |||
| No | 50 (65.8) | 26 (34.2) | 1 |
| Yes | 21 (63.6) | 12 (36.4) | 0.91 (.39–2.14) |
| Unknown/test not performed | 298 (83.7) | 58 (16.3) | 2.67 (1.54–4.64) |
| Other medical conditionsb | |||
| No | 207 (80.5) | 50 (19.5) | 1 |
| Yes | 162 (77.9) | 46 (22.1) | 0.85 (.54–1.33) |
| Syphilis stage | |||
| Primary | 100 (87.0) | 15 (13.0) | 1 |
| Secondary | 187 (85.8) | 31 (14.2) | 0.91 (.47–1.76) |
| Early latent | 82 (62.1) | 50 (37.9) | 0.25 (.13–.47) |
| Baseline RPR titer | |||
| ≤1:32 | 126 (62.7) | 75 (37.3) | 1 |
| >1:32 | 243(92.1) | 21 (8.0) | 6.89 (4.06–11.70) |
| Treatment regimen | |||
| Benzathine penicillin | 182 (79.1) | 48 (20.9) | 1 |
| Azithromycin | 187 (79.6) | 48 (20.4) | 1.03 (.66–1.61) |
| Jarisch-Herxheimer reaction | |||
| No | 223 (77.2) | 66 (22.8) | 1 |
| Yes | 146 (83.9) | 28 (16.1) | 1.54 (.95–2.52) |
Abbreviations: CI, confidence interval; OR, odds ratio; RPR, rapid plasma reagin.
a
Homosexual participants included 12 men who had sex with men and 2 women.
b
Other medical conditions included any other significantly relevant medical problems reported by participants that involved ≥1 organ systems.