MPs contain multiple MMPs. (A) Western blot detection of MMP-2, MMP-13, MMP-7, MMP-1 and plasminogen in MP and Sup protein samples treated with APMA or vehicle control. (B) MMP-2 ELISA analysis of MP and Sup samples. *** p < 0.001 (C) Fibrin zymography of and plasminogen western blot of MP and Sup fractions. Samples of plasmin (10 ng) were included in fibrin zymograms as positive controls. (D) Samples of microEC TP, MP, and Sup were analyzed by MMP-14, MMP-15, and MMP-16 western blots. Results are means ± SD.