MMPs are enriched in MMP- activities. (A) MicroEC Mem and MP samples, either treated with APMA or vehicle control, exhibited higher MMP activities than Sup samples in assays using 3 different fluorogenic MMP substrates. Asterisks above APMA values denote comparisons to corresponding vehicle control samples, while asterisks above Mem and MP vehicle control samples denote comparisons to Sup vehicle control samples. ** p < 0.01, *** p < 0.001 Results are means ± SD. (B) Gelatin zymography analysis of Mem, MP, and Sup fractions. (C) MMP-14 and pan-cadherin western blot analysis of microEC TP, Mem, MP, and Sup fractions.