Figure 6.
Neutralizing antibody to IL-6 (nAbTx) prevents the SDR-induced enhancement in virus induced CNS inflammation on day 8 post infection as measured by real time RT-PCR. An ANOVA followed by post hoc mean comparisons indicated that SDR-induced increases in IL-6 (A) and IL-1 β (B) mRNA expression were reversed by IL-6 nAbTx. A similar, but non-significant pattern was observed for CD11b mRNA expression (C), a cell surface marker increased in activated microglia. Asterisks indicate significant differences between groups.