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Block of IKur with 4-aminopyridine (4-AP, 50 μM) abbreviates APD90 in “healthy” (plateau-shaped action potential), but prolongs it in “acutely remodeled” (triangular-shaped action potential) canine coronary-perfused atrial preparations (pectinate muscles). Low flow ischemia was used to generate the “acutely remodeled” atria. Modified from Burashnikov et al. (Burashnikov et al., 2004; Burashnikov & Antzelevitch, 2008b), with permission.
