Table 2.

Genetic associations between lupus susceptibility loci and lupus in Gullah African-Americans adjusted by principal components. Two out of 15 SNPs examined were not included in the analysis due to low minor allele frequencies.

Gene	Marker	Chr	Position	Minor Allele	Minor Allele Frequency		95% CI			P value
					Cases	Controls	OR	LL	UL
FCGR2A	rs1801274	1	159746369	A	0.430 (129:171)	0.476 (117:129)	0.85	0.60	1.18	0.33
TNFSF4	rs2205960	1	171458098	A	0.092 (28:276)	0.020 (5:241)	4.99	1.85	13.43	0.0015
STAT4	rs7574865	2	191672878	A	0.150 (44:250)	0.107 (26:218)	1.39	0.85	2.29	0.19
CTLA4	rs231775	2	204440959	G	0.372 (113:197)	0.303 (74:170)	1.34	0.94	1.91	0.11
PXK	rs6445975	3	58345217	A	0.398 (121:183)	0.390 (96:150)	1.03	0.73	1.44	0.87
BANK1	rs10516487	4	102970099	A	0.211 (64:240)	0.262 (64:180)	0.74	0.50	1.10	0.14
MSH5	rs3131379	6	31829012	A	0.053 (16:288)	0.045 (11:235)	1.19	0.55	2.60	0.66
CFB	rs1270942	6	32026839	G	0.043 (13:291)	0.037 (9:237)	1.18	0.50	2.75	0.71
C8orf13-BLK	rs13277113	8	11386595	A	0.153 (46:254)	0.139 (34:210)	1.11	0.68	1.80	0.69
MBL2	rs1800450	10	54201241	A	0.016 (5:299)	0.016 (4:242)	1.02	0.27	3.90	0.98
KIAA1542	rs4963128	11	579564	A	0.389 (115:181)	0.438 (105:135)	0.82	0.58	1.15	0.25
ITGAM	rs1143679	16	31184312	A	0.191 (58:246)	0.110 (27:219)	1.97	1.19	3.26	0.0080
MECP2	rs17435	23	152965174	A	0.308 (95:209)	0.333 (81:165)	0.85	0.57	1.27	0.42

OR, odds ratio; LL, lower limit; UL, upper limit; CI, confidence interval. The numbers between parenthesis represent the number of minor and major alleles, respectively.

Odds ratios represent differences in the minor allele between cases and controls in each locus.