Table 3.
Meta-Analysis of genetic associations in the African-American samples combined with the Gullah African-American samples adjusted by principal component. Only the 13 SNPs that passed our quality control measures in both sample sets were included in this analysis.
| Gene | SNP | OR (95% CI) | Pmeta | PHeterogeneity | OR (95% CI) in European-derived populations (ref) |
|---|---|---|---|---|---|
| FCGR2A | rs1801274 | 0.88 (0.80–0.96) | 0.0070 | 0.81 | 0.86 (0.77–0.92) (67) |
| TNFSF4 | rs2205960 | 1.51 (1.24–1.86) | 5.7 × 10−5 | 0.02 | 1.22 (1.15–1.30) (67) |
| STAT4 | rs7574865 | 1.20 (1.06–1.37) | 0.0058 | 0.54 | 1.57 (1.49–1.69) (67) |
| CTLA4 | rs231775 | 1.15 (1.04–1.26) | 0.0045 | 0.38 | 1.60 (1.01–2.53) (68) |
| PXK | rs6445975 | 0.96 (0.87–1.05) | 0.36 | 0.67 | 0.80 (0.74–0.86)* (11) |
| BANK1 | rs10516487 | 0.78 (0.76–0.87) | 1.9 × 10−5 | 0.78 | 0.72 (0.66–0.80) (9) |
| MSH5 | rs3131379 | 1.63 (1.36–1.92) | 5.2 × 10−8 | 0.42 | 2.36 (2.11–2.64) (11) |
| CFB | rs1270942 | 1.60 (1.33–1.94) | 8.7 × 10−7 | 0.47 | 2.35 (2.10–2.63) (11) |
| C8orf13-BLK | rs13277113 | 1.34 (1.21–1.55) | 8.0 × 10−6 | 0.42 | 1.39 (1.28–1.51) (8) |
| MBL2 | rs1800450 | 1.11 (0.85–1.47) | 0.45 | 0.90 | 1.33 (1.08–1.65) (69) |
| KIAA1542 | rs4963128 | 0.86 (0.77–0.94) | 0.00099 | 0.80 | 0.83 (0.79–0.88) (67) |
| ITGAM | rs1143679 | 1.60 (1.37–1.83) | 7.5 × 10−11 | 0.40 | 1.78 (1.56–2.03) (17) |
| MECP2 | rs17435 | 1.04 (0.94–1.16) | 0.49 | 0.30 | 1.22 (1.07–1.38) (70) |
OR, odds ratio; CI, confidence interval. Odds ratios represent differences in the minor allele between cases and controls in each locus.
*
The minor allele for rs644975 PXK polymorphism is the C allele European-derived populations and is the A allele in African-Americans.