Figure 1. Effect of chlorpyrifos on cholinergic signs (involuntary movements) in wild type C57Bl/6 mice.
Mice (n = 5–6/group) were exposed to chlorpyrifos (75, 150 or 300 mg/kg, sc) and were graded for cholinergic signs of toxicity as described in Methods (reported as median ± interquartile range). Dose-related and time-dependent signs of toxicity were noted in mice treated with 150 or 300 mg/kg CPF.