Table 1.
Target gene | Cellular function | Fungus | Fungal features examinedb | Ref. | ||||
---|---|---|---|---|---|---|---|---|
37°C growth | Capsule | Melanin | Mating | Virulence | ||||
SOD1 | Cytoplasmic antioxidant |
Cg
Cn |
↔
↔ |
↓
↔ |
↓
↔ |
↔ ND |
↓
↓ |
67, 68 |
SOD2 | Mitochondrial antioxidant |
Cg
Cn |
↓
↓ |
↔ ND |
↔ ND |
↔ ND |
X X |
69, 70 |
TPS1 | Trehalose biosynthesis pathway |
Cg
Cn |
↓
↓ |
↓
↔ |
↓
↔ |
↓ ND |
↓ X |
71, 72 |
TPS2 | Trehalose biosynthesis pathway |
Cg
Cn |
X ↓ |
↓
↔ |
↓
↔ |
↔ ND |
↓
↔ |
71, 72 |
PKA1 | Regulation of cellular pathways |
Cg
Cn |
ND ND |
↓ X |
↔ X |
↔ X |
ND X |
74, 75 |
PKA2 | Regulation of cellular pathways |
Cg
Cn |
ND ND |
↓
↔ |
↓
↔ |
↑
↔ |
ND ND |
74, 75 |
STE12α | Regulation of mating |
Cg
Cn |
ND ↔ |
↔
↓ |
↓
↔ |
↓
↓ |
↓
↔ |
61, 73 |
C. neoformans refers to C. neoformans var. grubii.
Abbreviations: ND, not done; ↔, no change; ↓, reduced; ↑, enhanced; X, absent.