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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Trends Mol Med. 2011 Jul 26;17(11):617–624. doi: 10.1016/j.molmed.2011.06.002

Figure 1. The hippocampal network.

Figure 1

The hippocampus forms a unidirectional network with input arising from the entorhinal cortex that forms synaptic connections with the dentate gyrus (DG) via the perforant path (PP). Axons from DG project to CA3 pyramidal neurons via the mossy fibres pathway (MF). Axons from CA3 project to CA1 pyramidal neurons via the Schaeffer collateral pathway (SC). These CA1 neurons in turn send the main output back to the entorhinal cortex. CA3 and CA1 neurons can also receive input directly from the perforant path.