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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Trends Mol Med. 2011 Jul 26;17(11):617–624. doi: 10.1016/j.molmed.2011.06.002

Figure 2. Age-dependent neurodegeneration in the forebrain of presenilin conditional double knockout mice (FB-PS cDKO).

Figure 2

Comparison of nissl-stained coronal brain sections of age-matched control (left) and FB-PS cDKO (right) from 2 to 22 months of age. The nissl-stain dyes for cell bodies and is useful to examine cell sizes, numbers and overall morphology of the brain. No detectable differences were found at 2 months of age; however, there was a gradual decrease in cortical thickness with subsequent ages in FB-PS cDKO brains. Black bars delineate the cerebral cortex. Scale bar: 1 mm. (Adapted from Wines-Samuelson et al. [33])