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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2011 Jun 12;256(3):258–267. doi: 10.1016/j.taap.2011.05.021

Table 3.

Quantification of amacrine cell populations in the inner nuclear layer (INL)

Cell Counts Control Low Lead Moderate
Lead
High Lead
Wholemountsa TH (Dorsal) 16.5 ± 0.3 11.1 ± 0.7* 9.4 ± 0.5** 7.3 ± 0.6**
TH (Ventral) 17.3 ± 0.6 15.8 ± 0.3* 12.7 ± 0.4* 10.5 ± 0.3**
ChAT (Dorsal) 367 ± 16 371 ± 19 375 ± 21 359 ± 24
ChAT (Ventral) 372 ± 19 368 ± 22 368 ± 25 363 ± 18
Vertical Sectionsb ChAT 16 ± 3 17 ± 4 17 ± 3 16 ± 4
Dab1 17 ± 3 16 ± 4 15 ± 5 17 ± 4
GABA 7 ± 1 8 ± 1 7 ± 1 8 ± 2

TH: Tyrosine hydroxylase; IR: Immunoreactive; ChAT: Choline acetyltransferase; Dab1: Disabled1

a

Values represent the mean ± SEM for 500 µm2 of dorsal or ventral retina from three to nine different whole mounted mouse retinas per treatment group.

b

Values represent the means ± SEM for 40 µm fixed-frozen transverse sections from three non-adjacent slides for three to five different mouse retinas per treatment group.

*

p< 0.05 and

**

p<0.01 compared with corresponding controls.