Table 3.
Quantification of amacrine cell populations in the inner nuclear layer (INL)
| Cell Counts | Control | Low Lead | Moderate Lead |
High Lead | |
|---|---|---|---|---|---|
| Wholemountsa | TH (Dorsal) | 16.5 ± 0.3 | 11.1 ± 0.7* | 9.4 ± 0.5** | 7.3 ± 0.6** |
| TH (Ventral) | 17.3 ± 0.6 | 15.8 ± 0.3* | 12.7 ± 0.4* | 10.5 ± 0.3** | |
| ChAT (Dorsal) | 367 ± 16 | 371 ± 19 | 375 ± 21 | 359 ± 24 | |
| ChAT (Ventral) | 372 ± 19 | 368 ± 22 | 368 ± 25 | 363 ± 18 | |
| Vertical Sectionsb | ChAT | 16 ± 3 | 17 ± 4 | 17 ± 3 | 16 ± 4 |
| Dab1 | 17 ± 3 | 16 ± 4 | 15 ± 5 | 17 ± 4 | |
| GABA | 7 ± 1 | 8 ± 1 | 7 ± 1 | 8 ± 2 |
TH: Tyrosine hydroxylase; IR: Immunoreactive; ChAT: Choline acetyltransferase; Dab1: Disabled1
Values represent the mean ± SEM for 500 µm2 of dorsal or ventral retina from three to nine different whole mounted mouse retinas per treatment group.
Values represent the means ± SEM for 40 µm fixed-frozen transverse sections from three non-adjacent slides for three to five different mouse retinas per treatment group.
p< 0.05 and
p<0.01 compared with corresponding controls.