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. Author manuscript; available in PMC: 2012 Oct 2.
Published in final edited form as: Mol Immunol. 2011 Oct 2;49(1-2):367–379. doi: 10.1016/j.molimm.2011.09.008

Table III.

Bcl2 over-expression preferentially expands T1, T2 and MZ B cells in BrTg micea

C57Bl/6 control BrTg Bcl2 BrTg x Bcl2 Average fold- increase
Splenic cell numbers (× 106)
Total cells 109.6±18.5 c 90.5±13.2 533.3±18.9 575.4±63.9
CD19+ B cells 47.5±4.48 38.2.6±2.8 264.6±21.9 267.5±24.9
 T1b 5.63±0.81 7.39±0.76 14.4±2.45 35.7±4.22 2.5d
 T2 8.33±1.15 5.12±0.47 34.2±6.02 28.0±4.68 0.82
 T3 2.94±0.83 2.41±0.49 20.2±4.88 12.1±1.65 0.60
 MZ 2.25±0.27 3.69±0.32 7.08±2.22 40.1±7.17 5.7
 FO 26.2±2.98 15.3±1.30 144.0±10.5 75.3±9.99 0.52
a

Male and female mice (n = 7 to 11 mice per group) were analyzed at 8 to 12 weeks of age.

b

Splenic B cell subsets were defined as in Fig 1.

c

Total cell numbers (MEAN±SEM) per spleen were determined by multiplying the frequency of live gated cells by total cells and are shown ×106.

d

Average fold increase in BrTg x Bcl2 double transgenic mice compared to Bcl2 transgenic mice was calculated by dividing the average total cell numbers for each subset.