Table 3.

Dosage and frequency profiles of orally administered 5 kDa PEG-Av-p.C503S/p.C565S/p.F18A PAL in the PKU mouse model

			Reduction in plasma [Phe] (pre- versus 6 hours post-initial dosing)
Number of Doses	I.U./dose	Pre-dosing plasma [Phe] (uM ± s.e.m.)	(uM ± s.e.m.)	p value	compared with control treatment*(uM)
3	0.1	825.3 ± 65	193.5 ± 50	0.0317	332.9
3	0.3	1086.2 ± 75	226.43 ± 29	0.0142	365.8
3	1	945.6 ± 71	268.5 ± 106	0.0072	407.9
3	3	1052.4 ± 74	425.5 ± 66	0.0029	470.2
2	3	1038.9 ± 79	110.0 ± 60	0.7951	−51.5
1	3	1027.1 ± 80	445.9 ± 189	0.6599	87.4
3	6	998.7 ± 24	344.7 ± 104	0.0104	389.4
3	9	1044 ± 75	398.1 ± 106	0.0045	442.8

^*These values take into account the time equivalent, plasma [Phe] of control treated mice exposed to the same regimen of dosing.