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. Author manuscript; available in PMC: 2012 Dec 30.
Published in final edited form as: Immunol Lett. 2011 Sep 6;141(1):36–44. doi: 10.1016/j.imlet.2011.08.004

Figure 1.

Figure 1

Human IgE Fc-receptors and their soluble isoforms.

The high affinity IgE Fc receptor, Fc-epsilon-RI (FcεRI), has two transmembrane isoforms, FcεRIαβγ2 and FcεRIαγ2. The soluble isoform, sFcεRI, is a single chain receptor consisting of a truncated version of the IgE-binding FcεRIα subunit. Several different soluble isoforms of the transmembrane low affinity IgE Fc receptor, FcεRII or CD23, have been described. A detailed summary of soluble CD23 (sCD23) isoforms and their cleavage sites is provided in Table 2. Galectin-3 is a secretory IgE Fc receptor. After secretion, galectin-3 can attach to cell membranes via interacting with a large number of carbohydrate structures displayed by cell surface proteins. Additionally, an intracellular pool of galectin-3 can be found in the cytoplasm and the nucleus.