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Soluble IgE receptors in human serum
| Soluble IgE receptor | Main source in vivo | Regulation of production |
|---|---|---|
| sFcεRI – soluble alpha- chain of FcεRI | Not defined | IgE-mediated FcεRI activation |
| sCD23 | B cells | Surface expression of membrane CD23 and accessibility of cleavage sites Expression and activity of shedding enzymes ADAM10, ADAM8, ADAM33, MMP9 |
| Galectin-3 | Macrophages | Induction via IL-4 and IL-13 Inhibition by LPS and INF-γ |
