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. Author manuscript; available in PMC: 2012 Dec 30.
Published in final edited form as: Immunol Lett. 2011 Sep 6;141(1):36–44. doi: 10.1016/j.imlet.2011.08.004

Table 2.

Soluble CD23 isoforms

Molecular weight (kDa) Origin Enzyme
37 Extracellular shedding of membrane CD23 at position Ala80 in vivo: ADAM10 and MMP9
in vitro: ADAM10, ADAM8 and ADAM 33
33 Extracellular shedding of membrane CD23 at position Arg101 in vivo: ADAM10 and MMP9
in vitro: ADAM10, ADAM8 and ADAM 33
28–29 Intracellular processing of newly synthesized CD23 protein Not defined
25–27 Proteolytic cleavage/degradation products of 33kDa and 37kDa sCD23 Not defined
16–17 Extracellular cleavage of membrane CD23 at Ser155 and Glu298 Der p1