Table 4.
Major physiological roles of transmembrane and soluble IgE Fc receptors.
| IgE receptor | Transmembrane form | Soluble form |
|---|---|---|
| FcεRI | Mast cells, basophils: release of inflammatory mediators Dendritic cells: antigen uptake receptor |
Not defined |
| CD23 | Regulation of IgE sythesis Transport of IgE at mucosal surfaces |
Promotion of IgE sythesis Induction of inflammatory cytokine production from monocytes and macrophages Promotion of T and B cell differentation as well as B cell survival |
| Galectin-3a | Induction of inflammatory mediator release from mast cells via binding of FcεRI and IgE Promotion of adhesion, migration and respiratory burst of neutrophils Chemoattraction of monocytes and macrophages Promotion of Th2 responses and alternative macrophage activation Regulation of apoptosis in immune cells Anti-microbial functions against Candida albicans Activation and growth induction of tissue fibroblasts |
|
a
No transmembrane form of galectin-3 exists. Next to the secreted pool, galectin-3 is found intracellularly in a non-secreted form.