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Human and feline APOBEC3 (A3) proteins. (a) Schematic representation of human and feline A3 cytidine deaminases. All A3 proteins share at least one zinc (Z)-coordinating catalytic motif. The color code indicates the amino acid specificity of the different deaminase domains (Z1, Z2 and Z3). Humans express seven A3 proteins, A3A–A3H; cats express four A3 proteins, A3Z2a–A3Z2-Z3. (b) Amino acid sequences of indicated domains. Group-specific distinctions of Z-domains are highlighted.
