Figure 3.

Domain structure of TRIM5α and TRIMCyp proteins. (a) TRIM5α is defined by four domains: RING finger, B-box 2, coiled-coil and B30.2. The feline TRIM5α lacks the B30.2 capsid-binding domain because of a premature stop codon in the mRNA transcript. (b) In some monkeys, TRIMCyp is expressed, in which the B30.2 domain of TRIM5α is replaced with a cyclophilin A (CypA) domain. Expression of feline TRIMCyp was not observed. Dietrich et al. produced a synthetic feline TRIMCyp by fusion of the truncated TRIM5α and feline cyclophilin A [75].