Table 2.

Clamp-derived measures and surrogate indices of insulin sensitivity by glucose tolerance group

	NGT (1), n = 101	IGT (2), n = 50	T2DM (3), n = 23	OB-T1DM (4), n = 14	P, ANOVA	P, post hoc
						1 vs. 2	1 vs. 3	1 vs. 4	2 vs. 3	2 vs. 4	3 vs. 4
SIEuClamp (mg/kg · min per μU/ml)	2.5 ± 0.1	1.9 ± 0.2	1.6 ± 0.2	3.3 ± 0.5	<0.001	0.06	0.03	NS	NS	<0.01	<0.01
SIEuClamp (mg/kg FFM · min per μU/ml)	4.5 ± 0.2	3.5 ± 0.3	3.0 ± 0.4	5.7 ± 0.7	<0.001	0.04	0.01	NS	NS	<0.01	<0.01
GF (mg/dl)	94.8 ± 0.6	96.9 ± 1.0	117 ± 4.5	131 ± 11	<0.001	NS	<0.001	<0.001	<0.001	<0.001	0.02
IF (μU/ml)	32.3 ± 1.6	48.8 ± 4.2	44.8 ± 5.5	25.1 ± 2.5	<0.001	<0.001	0.08	NS	NS	<0.01	0.05
1/IF	0.038 ± 0.002	0.028 ± 0.002	0.030 ± 0.003	0.047 ± 0.005	<0.001	<0.01	NS	NS	NS	<0.01	0.02
GF/IF	3.6 ± 0.2	2.7 ± 0.2	3.4 ± 0.3	6.0 ± 0.8	<0.001	<0.01	NS	<0.001	NS	<0.001	<0.001
QUICKI	0.292 ± 0.002	0.279 ± 0.003	0.275 ± 0.004	0.290 ± 0.005	<0.001	<0.001	<0.01	NS	NS	NS	NS
HOMA-IS	0.30 ± 0.01	0.22 ± 0.02	0.23 ± 0.03	0.34 ± 0.04	<0.001	<0.01	0.06	NS	NS	0.01	0.05
WBISI	2.1 ± 0.1	1.2 ± 0.1	1.4 ± 0.2	2.3 ± 0.3	<0.001	<0.001	0.02	NS	NS	<0.01	0.07
GlucAUC/InsAUC	1.1 ± 0.1	0.81 ± 0.1	2.2 ± 0.4	6.2 ± 1.0	<0.001	NS	<0.01	<0.001	<0.001	<0.001	<0.001

NS, Not significant.