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. 2011 Oct 15;25(20):2173–2186. doi: 10.1101/gad.17221311

Figure 3.

Figure 3.

High-confidence microRNA-302/367 targets. (A) The intersection between PAR-CLIP data and the miR-302/367 perturbation experiments identifies the set of most regulated targets. The set of 146 high-confidence miR-302/367 targets is defined as those genes with favorable mirSVR scores (Betel et al. 2010) that are significantly up-regulated after miR-302/367 inhibition and have identified PAR-CLIP sites in their 3′ UTRs. (B) The full list of high-confidence miR-302/367 targets in undifferentiated hESCs. Included in this list are a number of previously identified miR-302 targets (e.g., LEFTY1/2 [Rosa et al. 2009], CDKN1A [Wang et al. 2008], and TGFBR2 [Subramanyam et al. 2011]), many that are implicated in cell cycle regulation (e.g., BTG1,2,3), and negative regulators of BMP and TGF-β signaling.