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. 2011 Oct 15;25(20):2187–2197. doi: 10.1101/gad.16974811

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Copyright © 2011 by Cold Spring Harbor Laboratory Press

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Figure 6. — Prox1 haploinsufficiency is the result of a reduction in Coup-TFII/Prox1 interaction. Prox1^+/NR and Tie2-Cre;Coup-TFII^+/f mice were bred and the resulting embryos were analyzed at E15.5 by whole mount or by immunohistochemistry on frontal sections with antibodies against Prox1, podoplanin (pdpn), and PECAM1. (A–D) Prox1^+/NR and Tie2-Cre;Coup-TFII^+/f embryos are phenotypically normal with unremarkable valves. Instead, Tie2-Cre;Coup-TFII^+/f; Prox1^+/NR embryos are edematous (E, arrow), devoid of Prox1⁺ cells in the veins (F, arrows), and lack lymphovenous valves. In the sections, the head is oriented toward the right, the heart is oriented toward the left, and the thymus is oriented toward the bottom in all panels. (LS) Lymph sac. Bar, 50 μm.