Table 3.
Parasitologic cure rate at day 28 for patients treated with artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria*
| Group | Adults (all patients) | Adults (Study A2401) | Children | |||
|---|---|---|---|---|---|---|
| No./total (%) | 95% CI | No./total (%) | 95% CI | No./total (%) | 95% CI | |
| mITT population | ||||||
| Non-PCR corrected | 497/599 (83.0) | 79.7–85.9 | 120/162 (74.1) | 66.6–80.6 | 743/863 (86.1) | 83.6–88.3 |
| PCR corrected† | 499/598 (83.4) | 80.2–86.3 | 120/162 (74.1)‡ | 66.6–80.6 | 798/854 (93.4) | 91.6–95.0 |
| Evaluable patients | ||||||
| Non-PCR corrected | 494/511‡ (96.7) | 94.7–98.1 | 119/124 (96.0) | 90.8–98.7 | 737/823 (89.6) | 87.3–91.6 |
| PCR corrected† | 495/510§¶ (97.1) | 95.2–98.3 | 119/124 (96.0) | 90.8–98.7 | 792/814 (97.3) | 95.9–98.3 |
*
CI = confidence interval; mITT = modified intent-to-treat; PCR = polymerase chain reaction.
†
PCR analysis was not performed in study A2401.
‡
Two patients were excluded from this analysis after starting antimalarial treatments before day 28 (for reasons other than rescue medication).
§
Last observation carried forward: 147 of 162 (90.7%).
¶
One patient was excluded because of a new infection that started before day 28.